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Coming off Mounjaro or Wegovy
Stopping weight loss medication deserves as much clinical thought as starting it. Appetite returns, and without a plan the weight often follows. Medical Weight Care supports people who are coming off Mounjaro or Wegovy (including Wegovy tablets), or newer treatments such as Foundayo (orforglipron) tablets, who have already stopped and are seeing the weight return, or who want to begin treatment again after a break — whether or not the original prescription came from us.
COMING OFF, AND AFTER
Stopping needs a plan as much as starting did
Most of the advice about weight loss injections and tablets is about getting on them. Very little is about getting off them well. Appetite comes back, and if nothing else has changed, the weight usually does too. That is how the biology works, and it is what a doctor can help you plan around.
Open to people prescribed elsewhere
Doctor-led throughout
Free 20–30 minute first appointment
Why people stop
None of these reflect a lack of commitment, and you will not be talked out of your decision here.
The cost
These are long-term treatments and the monthly expense climbs with the dose. It is the most common reason people stop, and the least often discussed honestly.
Side effects
Mostly digestive, and for most people they settle. When they do not, continuing is not always the right answer.
You have got there
You reached the weight you were aiming for and want to find out how you manage without it. That is a good reason, and a good moment to plan carefully.
What actually happens when you stop
Worth knowing before you decide, rather than discovering it three weeks later.
Appetite returns, usually within a week or two
The medication works by acting on the hormones that regulate hunger and slow digestion. Take it away and those signals resume. The change can feel abrupt.
Regain is common without support
The systems controlling appetite and fat storage push back towards where they were. This is the same biology that made losing the weight hard in the first place, and it responds to the same medical attention.
Stopping suddenly from a high dose is rarely the best route
A planned reduction, agreed with a doctor who knows your history, gives your body and your habits time to adjust.
Beginning again is not a matter of picking up where you left off
Everyone is different, and the right starting dose is decided at your assessment. After a break, treatment usually begins again at the lowest dose and builds up, to limit side effects.
This page describes what generally happens. What happens for you depends on your dose, how long you have been taking it, your medical history and a good deal else — which is what the first appointment is for.
How the support works
A doctor-led route out of medication, or back into it, built around where you actually are.
1
An honest assessment of where you are
3
Support through the period that matters most
Your current dose, how long you have been on it, what has happened to your weight, what your eating looks like now, and what you want the next year to look like.
The weeks after stopping are when appetite returns and habits are tested. Regular review, practical dietary support, and someone to speak to when it gets difficult.
2
A reduction planned with you, not handed to you
4
Beginning again, properly, if you need to
Where you are coming off, the doctor agrees a paced reduction with you rather than a sudden stop — adjusted as you go if appetite or weight change faster than expected.
If the weight begins to return and going back on treatment is the right call, that is a clinical decision made with assessment and correct re-titration — not a repeat prescription.
Three situations this is built for
Still taking it, thinking about stopping
The best time to plan. Come and talk it through before you stop rather than after.
Stopped already, weight creeping back
Very common, and there is a great deal that can be done from here.
Want to start again after a break
Beginning again safely means assessment and re-titration. Bring whatever records you have from your previous prescriber.
You do not need to have been a Medical Weight Care patient. If your medication came from an online pharmacy or another clinic, that is fine — bring what you know about your dose and how long you have been taking it.
Questions about coming off treatment
Does this apply to tablets as well?
Yes. The same support is available whether you take Mounjaro or Wegovy injections, Wegovy tablets or Foundayo (orforglipron) tablets. Everyone is different, and your plan is decided at assessment.
I was prescribed elsewhere. Can you still help?
Yes. You do not need to have been a Medical Weight Care patient. If your medication came from an online pharmacy or another clinic, bring what you know about your dose and how long you have been taking it.
What happens when I stop?
Appetite usually returns within a week or two, and without support the weight often comes back. A planned reduction, agreed with a doctor who knows your history, gives your body and your habits time to adjust.
Can I start again after a break?
If going back on treatment is the right clinical decision, yes. Everyone is different, and the right starting dose is decided at your assessment. After a break, treatment usually begins again at the lowest dose and builds up.
Does the first appointment cost anything?
No. It is a free 20–30 minute conversation with the doctor, with no expectation that you continue.